Guidelines for Developmental Toxicity Risk Assessment

Guidelines for Developmental Toxicity Risk Assessment

policy and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. Note: This document represents the final guidelines. A number of editorial corrections have been made during conversion and subsequent proofreading to ensure the accuracy of this publication.

Ecological Risk Assessment of a Tropical Lake System

Risk analysis of urban aquatic systems due to heavy metals turns significant due to their peculiar properties viz. persistence, non-degradability, toxicity, and accumulation. Akkulam Veli (AV), an urban tropical lake in south India is subjected to various environmental stresses due to multiple waste discharge, sand mining, developmental activities, tourism related activities etc. Hence, a compr...

Current and future needs for developmental toxicity testing.

A review is presented of the use of developmental toxicity testing in the United States and international regulatory assessment of human health risks associated with exposures to pharmaceuticals (human and veterinary), chemicals (agricultural, industrial, and environmental), food additives, cosmetics, and consumer products. Developmental toxicology data are used for prioritization and screening...

Methods to identify and characterize developmental neurotoxicity for human health risk assessment: overview.

issued a standardized protocol for evaluation of developmental neuro-toxicity (DNT) for use in human health risk assessment (1). Briefly, the protocol comprises a) tests for evidence of deficits in neurobehav-ioral functions including auditory startle, habituation, associative learning and memory; b) monitoring of motor activity; and c) neu-ropathologic examination including simple morphometric...

Guidelines for Reproductive Toxicity Risk Assessment